Sigma-1 receptor antagonist 1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sigma-1受体拮抗剂1是一种有效的、选择性的sigma-1受体拮抗剂。

Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor. Sigma-1 receptor antagonist 1 exhibits antineuropathic pain activity and can be used in the treatment of neuropathic pain studies.(In Vitro):Sigma?1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor with Ki of 1.06 nM and good σ-1/2 selectivity (1344-fold).(In Vivo):In mice formalin model and rats CCI models of neuropathic pain, Sigma?1 receptor antagonist 1 exerts dose-dependent antinociceptive effects.

Sigma?1 receptor antagonist 1 exhibits a high binding affinity to σ1R receptor (Ki = 1.06 nM) and good σ-1/2 selectivity (1344-fold).

Sigma1 receptor antagonist 1 exerts dose-dependent antinociceptive effects in mice formalin model and rats CCI models of neuropathic pain.

——

Autophagy

Sigma receptor

TLR7| TLR8

——

——

1639220-19-1

380.31

C19H23Cl2N3O

>98% (HPLC)

In Vitro:?DMSO : 6.25 mg/mL (16.43 mM)

Cc1nc(nc(OCCCN2CCCCC2)c1Cl)-c1ccc(Cl)cc1

——

(-20℃)

With Ice Pack

≥ 2 years